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Synthesis of Benzocaine

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Ethyl aminobenzoate,(benzocaine), is derived from para aminobenzoic acid,(PABA), by way of a Fischer esterfication reaction involving the reflux of ethanol with an acid catalyst. The ester formed, an amine salt of benzocaine, is converted to benzocaine by the addition of NaOH. The reaction consists of 3 grams PABA, 20ml ethanol, and 3ml sulfuric acid refluxed for 82-90 min, conversion of the amine salt with NaOH, and then washed and filtered with distilled water. Ethyl aminobenzoate or "benzocaine", is a topical anesthetic used in over the counter medicines. Thanks to Ameera Patel for the research and lab procedure.